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石北 央 (Hiroshi Ishikita) 教授 CV

石北 央 Hiroshi Ishikita

先端科学技術研究センター
工学系研究科 応用化学専攻
hiro☆appchem.t.u-tokyo.ac.jp

1998. 3.31東京大学 工学部 化学生命工学科卒
:長棟輝行教授
2000. 3.31東京大学 大学院工学系研究科 化学生命工学専攻 修士課程 修了
:長棟輝行教授

【ドイツ】

2000. 6. 1
-2004. 3.31
DAADドイツ学術交流会奨学生(DAAD Stipendiat)
2000. 6. 1DAADによるドイツ語研修期間(4ヶ月)、ブレーメン
2000.10. 1Freie Universitaet Berlin (Free University of Berlin)
:Prof. Dr. Ernst-Walter Knapp
2004. 4. 1Freie Universitaet Berlin, Wissenschaftlicher Mitarbeiter
:Prof. Dr. Ernst-Walter Knapp
2005.11.25Ph.D. (Dr. rer. Nat.)授与
:口頭、筆記、総合全てsumma cum laudeの成績にて
(Prof. Dr. Ernst-Walter Knapp/ Prof. Dr. Wolfram Saenger)

【アメリカ】

2005.12. 1The Pennsylvania State University, Postdoc
:Prof. Sharon Hammes-Schifferの研究室
2006.12. 1University of Southern California, Postdoc
:Prof. Arieh Warshelの研究室
2007.4.1日本学術振興会 海外特別研究員(面接免除採用)
:Prof. Arieh Warshelの研究室

【日本】

2008. 4. 1東京大学 分子細胞生物学研究所 助教
2009. 1. 1京都大学 生命科学系キャリアパス形成ユニット 特定助教(独立) (注)
2013. 4. 1京都大学 生命科学系キャリアパス形成ユニット 講師(独立)
2013. 7. 1大阪大学 大学院理学研究科 生物科学専攻 教授
2014. 4. 1東京大学 大学院工学系研究科 応用化学専攻 教授
2014. 7. 1東京大学 先端科学技術研究センター 教授 
(大学院工学系研究科 応用化学専攻 兼担)
(注)
2009.10. 1科学技術振興機構 さきがけ研究者(兼任)
「光エネルギーと物質変換」領域 (~2013.3.31)

【表彰】

2009年8月武田科学振興財団 生命科学研究奨励
2013年4月文部科学大臣表彰 若手科学者賞
2013年5月JSTさきがけ「光エネルギーと物質変換」研究領域
The Chemical Conversion of Light Energy Prize 2013

PUBLICATION

  1. Hiroshi Ishikita, Giulia Morra, and Ernst-Walter Knapp*
    Biochemistry 42 (2003) 3882-3892
    “Redox potential of quinones in photosynthetic reaction centers from Rhodobacter sphaeroides: dependence on protonation of Glu-L212 and Asp-L213″
    Journal PubMed
  2. Hiroshi Ishikita and Ernst-Walter Knapp*
    J. Biol. Chem. 278 (2003)  52002-52011
    “Redox potential of quinones in both electron transfer branches of photosystem I”
    Journal PubMed
  3. Hiroshi Ishikita and Ernst-Walter Knapp*
    J. Am. Chem. Soc. 126 (2004)  8059-8064
    “Hydrogen bond between Ser-L223 and QB: protonation of Asp-L213 in the reaction center of Rhodobacter sphaeroides
    Journal PubMed
  4. Hiroshi Ishikita, Bernhard Loll, Jacek Biesiadka, Artur Galstyan, Wolfram Saenger and Ernst-Walter Knapp*
    FEBS Lett. 579 (2005) 712-716
    “Tuning electron transfer by ester-group of chlorophylls in bacterial photosynthetic reaction center”
    Journal PubMed
  5. Hiroshi Ishikita and Ernst-Walter Knapp
    J. Am. Chem. Soc. 127 (2005) 1963-1968
    “Redox potentials of chlorophylls and b-carotene in the antenna complexes of photosystem II”
    Journal PubMed
  6. Hiroshi Ishikita and Ernst-Walter Knapp*
    J. Biol. Chem. 280 (2005) 12446-12450
    “Energetics of proton transfer pathways in reaction centers from Rhodobacter sphaeroides. The Glu-H173 activated mutants”
    Journal PubMed
  7. Hiroshi Ishikita, Bernhard Loll, Jacek Biesiadka, Wolfram Saenger and Ernst-Walter Knapp
    Biochemistry 44 (2005) 4118-4124
    “Redox potentials of chlorophylls in the photosystem II reaction center”
    JournalPubMed
  8. Hiroshi Ishikita and Ernst-Walter Knapp*
    FEBS Lett579 (2005) 3190-3194
    “Redox potential of cytochrome c550 in the cyanobacterium Thermosynechococcus elongatusJournal PubMed
  9. Hiroshi Ishikita and Ernst-Walter Knapp*
    J. Am. Chem. Soc. 127 (2005) 14714-14720
    “Control of quinone redox potentials in photosystem II: electron transfer and photoprotection”
    Journal PubMed
  10. Hiroshi Ishikita and Ernst-Walter Knapp*
    Biochemistry 44 (2005) 14772-14784
    “Oxidation of the non-heme iron complex in photosystem II”
    Journal PubMed
  11. Hiroshi Ishikita and Ernst-Walter Knapp*
    Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 16215-16220 [Direct Submission, Edited by H. Gray]
    “Induced conformational changes upon Cd2+ binding at photosynthetic reaction centers”
    Journal PubMed
  12. Hiroshi Ishikita, Dietmar Stehlik, John H. Golbeck and Ernst-Walter Knapp*
    Biophys. J. 90 (2006) 1081-1089
    “Electrostatic influence of PsaC protein binding to the PsaA/PsaB heterodimer in Photosystem I”
    Journal PubMed
  13. Hiroshi Ishikita, Wolfram Saenger, Bernhard Loll, Jacek Biesiadka, and Ernst-Walter Knapp*
    Biochemistry 45 (2006) 2063-2071
    “Energetics of a possible proton exit pathway for water oxidation in Photosystem II”
    Journal PubMed
  14. Hiroshi Ishikita, Jacek Biesiadka, Bernhard Loll, Wolfram Saenger, and Ernst-Walter Knapp*
    Angew. Chem. 118 (2006) 1998-1999
    Angew. Chem. Int. Ed. Engl. 45 
    (2006) 1964-1965
    “Cationic state of accessory chlorophyll and electron transfer through pheophytin to plastoquinone in photosystem II”
    Journal PubMed
  15. Hiroshi Ishikita and Ernst-Walter Knapp*
    Biophys. J.  90 (2006) 3886-3896
    “Function of redox-active tyrosine in photosystem II”
    Journal PubMed
  16. Hiroshi Ishikita, Wolfram Saenger, Jacek Biesiadka, Bernhard Loll, and Ernst-Walter Knapp*
    Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 9855-9860 [Direct Submission, Edited by H. Gray]
    “How photosynthetic reaction centers control oxidation power in chlorophyll pairs P680, P700 and P870”
    Journal PubMed
  17. Hiroshi Ishikita and Ernst-Walter Knapp*
    FEBS Lett. 580 (2006) 4567-4570
    “Electrostatic role of the non-heme iron complex in bacterial photosynthetic reaction center”
    Journal PubMed
  18. Hiroshi Ishikita*, Bernhard Loll, Jacek Biesiadka, Jan Kern, Klaus-Dieter Irrgang, Athina Zouni, Wolfram Saenger and Ernst-Walter Knapp
    Biochim. Biophys. Acta  (Bioenergetics) 1767 (2007) 79-87 
    “Function of two beta-carotenes near the D1 and D2 proteins in photosystem II dimers”
    Journal PubMed
  19. Hiroshi Ishikita* and Ernst-Walter Knapp
    J. Am. Chem. Soc.129 (2007) 1210-1215
    “Protonation states of ammonia/ammonium in the hydrophobic pore of ammonia transporter protein AmtB”
    Journal PubMed
  20. Irina Karygina, Dietmar Stehlik, Ingelog Wyndhamn, Art van der Est, Hiroshi Ishikita, Ernst-Walter Knapp, Barath Jaganathan, Rufat Agalarov, and John H. Golbeck*
    Biochemistry 46 (2007) 10804-10816
    “Contributions of the distant protein environment to the redox potentials of the A1 phylloquinone and the FX iron-sulfur cluster in photosystem I”
    Journal PubMed
  21. Hiroshi Ishikita, Alexander V. Soudackov and Sharon Hammes-Schiffer*
    J. Am. Chem. Soc. 129 (2007)  11146-11152
    “Buffer-assisted proton-coupled electron transfer in a model rhenium-tyrosine complex”
    Journal PubMed
  22. Hiroshi Ishikita*
    FEBS Lett. 581 (2007) 4293-4297
    “Modulation of the protein environment in the hydrophilic pore of the ammonia transporter protein AmtB upon the GlnK protein binding”
    Journal PubMed
  23. Hiroshi Ishikita*
    J. Biol. Chem282 (2007) 25240-25246
    “Contributions of protein environment to redox potentials of quinones in flavodoxins from Clostridium beijerinckii
    Journal PubMed
  24. Hiroshi Ishikita, Artur Galstyan, and Ernst-Walter Knapp*
    Biochim. Biophys. Acta  (Bioenergetics) 1767(2007) 1300-1309
    “Redox potential of the non-heme iron complex in bacterial photosynthetic reaction center”
    Journal Pubmed
  25. Frank Müh, Mohamed El-Amine Madjet, Julia Adolphs, Ayjamal, Abdurahman, Björn Rabenstein, Hiroshi Ishikita, Ernst-Walter Knapp, and Thomas Renger*
    Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 16862-16867 [Communicated by R. A. Marcus]”alpha-Helices direct excitation energy flow in the Fenna-Matthews-Olson protein”
    Journal Pubmed
  26. Sharon Hammes-Schiffer*, Elizabeth Hatcher, Hiroshi Ishikita, Jonathan Skone, and Alexander V. Soudackov
    Coord. Chem. Rev252 (2008) 384-394
    “Theoretical studies of proton-coupled electron transfer: models and concepts relevant to bioenergetics”
    Pubmed
  27. Hiroshi Ishikita and Arieh Warshel*
    Angew. Chem. 120 (2008) 709-712
    Angew. Chem. Int. Ed. Engl. 47 
    (2008) 697-700
    “Predicting drug resistant mutations of HIV protease”
    Journal Pubmed
  28. Hiroshi Ishikita*
    Biochemistry 47 (2008) 4394-4402
    “Redox potential difference between Desulfovibrio vulgaris and Clostridium beijerinckii flavodoxins”
    Journal Pubmed
  29. Hiroshi Ishikita*
    J. Biol. Chem. 283 (2008) 30618-30623
    “Light-induced hydrogen bonding pattern and driving force of electron transfer in AppA BLUF domain photoreceptor”
    Journal Pubmed
  30. Hiroshi Ishikita*
    FEBS Lett. 584 (2010) 3464-3468
    “Origin of the pKa shift of the catalytic lysine in acetoacetate decarboxylase”
    Journal Pubmed
  31. Ana Patricia Gamiz-Hernandez, Gernot Kieseritzky, Hiroshi Ishikita, and Ernst-Walter Knapp*
    J. Chem. Theory Comput. 7 (2011) 742-752
    “Rubredoxin function: redox behavior from electrostatics”
    Journal
  32. Hiroshi Ishikita*
    PLoS One 6 (2011) e16920, 1-7
    “Proton-binding sites of acid-sensing ion channel 1”
    Journal Pubmed
  33. Hiroshi Ishikita*, Koji Hasegawa, and Takumi Noguchi
    Biochemistry 50 (2011) 5436-5442
    “How does the QB site influence propagate to the QA site in Photosystem II?”
    Journal Pubmed
  34. Hiroshi Ishikita*
    PLoS One 6 (2011) e26808, 1-5
    “Tyrosine deprotonation and associated hydrogen bond rearrangements in a photosynthetic reaction center”
    Journal Pubmed
  35. Keisuke Saito, Toyokazu Ishida, Miwa Sugiura, Keisuke Kawakami, Yasufumi Umena, Nobuo Kamiya, Jian-Ren Shen, and Hiroshi Ishikita*
    J. Am. Chem. Soc. 133 (2011) 14379-14388
    “Distribution of the cationic state over the chlorophyll pair of photosystem II reaction center”
    Journal Pubmed
  36. Keisuke Saito and Hiroshi Ishikita*
    Biophys. J. 101(2011) 2018-2025
    “Cationic state distribution over the P700 chlorophyll pair in Photosystem I”
    Journal Pubmed
  37. Keisuke Saito, Jian-Ren Shen, Toyokazu Ishida, and Hiroshi Ishikita*
    Biochemistry 50 (2011) 9836-9844
    “Short hydrogen-bond between redox-active tyrosine YZ and D1-His190 in the photosystem II crystal structure”
    Journal Pubmed
  38. Keisuke Saito and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 109 (2012) 167-172 [Direct Submission, Edited by A. Fersht]
    “Energetics of short hydrogen bonds in photoactive yellow protein”
    Journal Pubmed
  39. Keisuke Saito, Jian-Ren Shen, and Hiroshi Ishikita*
    Biochim. Biophys. Acta  (Bioenergetics) 1817 (2012) 1191-1195
    “Cationic state distribution over the chlorophyll d-containing PD1/PD2 pair in photosystem II”
    Journal Pubmed
  40. Hiroshi Ishikita*, Bryan T. Eger, Ken Okamoto, Takeshi Nishino, and Emil F. Pai
    J. Am. Chem. Soc. 134 (2012) 999-1009
    “Protein conformational gating of enzymatic activity in xanthine oxidoreductase”
    Journal Pubmed
  41. Keisuke Saito and Hiroshi Ishikita*
    Biochemistry 51 (2012) 1171-1177
    “H atom positions and nuclear magnetic resonance chemical shifts of short H bonds in photoactive yellow protein”
    Journal Pubmed
  42. Keisuke Saito, Jian-Ren Shen, and Hiroshi Ishikita*
    Biophys. J. 102 (2012) 2634-2640
    “Influence of the axial ligand on the cationic properties of the chlorophyll pair in photosystem II from Thermosynechococcus vulcanus
    Journal Pubmed
  43. Keisuke Saito, Yasufumi Umena, Keisuke Kawakami, Jian-Ren Shen, Nobuo Kamiya, and Hiroshi Ishikita*
    Biochemistry 51 (2012) 4290-4299
    “Deformation of chlorin rings in the photosystem II crystal structure”
    Journal Pubmed
  44. Keisuke Saito, Hideki Kandori, and Hiroshi Ishikita*
    J. Biol. Chem. 287 (2012) 34009-34018
    “Factors that differentiate the H-bond strengths of water near the Schiff bases in bacteriorhodopsin and Anabaena sensory rhodopsin”
    Journal Pubmed
  45. Keisuke Saito and Hiroshi Ishikita*
    Biochim. Biophys. Acta  (Bioenergetics) 1827 (2013) 387-394
    “Formation of an unusually short hydrogen bond in photoactive yellow protein”
    Journal Pubmed
  46. Keisuke Saito, A. William Rutherford, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 110 (2013) 954-959 [Direct Submission, Edited by P. Joliot]
    “Mechanism of proton-coupled quinone reduction in Photosystem II”
    Journal Pubmed
  47. Keisuke Saito, A. William Rutherford, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 110 (2013) 7690-7695 [Direct Submission, Edited by H. Gray]
    “Mechanism of Tyrosine D oxidation in Photosystem II”
    Journal Pubmed
  48. Keisuke Saito and Hiroshi Ishikita*
    Biochim. Biophys. Acta  (Bioenergetics) 1837 (2014) 159-166
    “Influence of the Ca2+ ion on the Mn4Ca conformation and the H-bond network arrangement in Photosystem II”
    Journal Pubmed
  49. Hiroshi Ishikita* and Keisuke Saito
    J. R. Soc. Interface 11(2014) 20130518 doi: 10.1098/rsif.2013.0518
    “Proton transfer reactions and hydrogen-bond networks in protein environments”
    Journal Pubmed
  50. Keisuke Saito, A. William Rutherford, and Hiroshi Ishikita*
    Nat. Commun. 6:8488 (2015) doi: 10.1038/ncomms9488
    “Energetics of proton release on the first oxidation step in the water-oxidizing enzyme”
    Journal Pubmed
  51. Tomohiro TakaokaNaoki SakashitaKeisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. (2016) 1925-1932
    “pKa of a proton conducting water chain in photosystem II”
    Journal Pubmed
  52. Keisuke Saito*Naoki Sakashita, and Hiroshi Ishikita
    Aust. J. Chem. 69 (2016) 991-998
    “Energetics of the proton transfer pathway for tyrosine D in photosystem II”
    Journal
  53. Kento Motoyama, Hideaki Unno, Ai Hattori, Tomohiro TakaokaHiroshi Ishikita, Hiroshi Kawaide, Tohru Yoshimura, and Hisashi Hemmi*
    J. Biol. Chem. 292(2017) 2457-2469
    “A single amino acid mutation converts (R)-5-diphosphomevalonate decarboxylase into a kinase”
    Journal Pubmed
  54. Naoki SakashitaHiroshi C. WatanabeTakuya Ikeda, and Hiroshi Ishikita*
    Photosynth. Res. 133 (2017) 75-85. doi: 10.1007/s11120-017-0347-1
    “Structurally conserved channels in cyanobacterial and plant photosystem II”
    Journal Pubmed
  55. Hiroshi C. WatanabeYuki Yamashita, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 114 (2017) 2916-2921 [Direct Submission, Edited by A. Warshel]
    “Electron transfer pathways in a multi-heme cytochrome MtrF”
    Journal Pubmed
  56. Ryo Hasegawa, Keisuke Saito, Tomohiro Takaoka, and Hiroshi Ishikita*
    Photosynth. Res. 133 (2017) 297-304. doi: 10.1007/s11120-017-0382-y
    “pKa of ubiquinone, menaquinone, phylloquinone, plastoquinone, and rhodoquinone in aqueous solution”
    Journal Pubmed
  57. Keisuke Kawashima and Hiroshi Ishikita*
    Biochemistry 56 (2017) 3019-3028. doi: 10.1021/acs.biochem.7b00082
    “Structural factors that alter the redox potential of quinones in cyanobacterial and plant photosystem I”
    Journal Pubmed
  58. Naoki Sakashita, Hiroshi C. Watanabe, Takuya Ikeda, Keisuke Saito, and Hiroshi Ishikita*
    Biochemistry 56 (2017) 3049-3057. doi: 10.1021/acs.biochem.7b00220
    “Origins of water molecules in the photosystem II crystal structure”
    Journal Pubmed
  59. Takuya IkedaKeisuke SaitoRyo Hasegawa, and Hiroshi Ishikita*
    Angew. Chem. 129 (2017) 9279-9282. doi: 10.1002/ange.201705512
    Angew. Chem. Int. Ed. 56
     (2017) 9151-9154. doi: 10.1002/anie.201705512
    “Existence of isolated H3O+ in the protein interior”
    Journal Pubmed
  60. Hiroshi C. Watanabe*, Maximilian Kubillus, Tomas Kubar, Robert Stach, Boris Mizaikoff, and Hiroshi Ishikita
    Phys. Chem. Chem. Phys. 19 (2017) 17985-17997. doi: 10.1039/C7CP01708A
    “Cation solvation with quantum chemical effects modeled by size-consistent multi-partitioning quantum mechanics/molecular mechanics method”
    Journal Pubmed
  61. Shinnosuke KishiKeisuke Saito, Yuki Kato, and Hiroshi Ishikita*
    Photosynth. Res. 134 (2017) 193-200. doi: 10.1007/s11120-017-0433-4
    “Redox potentials of ubiquinone, menaquinone, phylloquinone, and plastoquinone in aqueous solution”
    Journal Pubmed
  62. Hiroshi C. WatanabeYuki Yamashita, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 114 (2017) E10029-E10030. doi: 10.1073/pnas.1717048114
    “Molecular dynamics simulations do not provide functionally relevant values of redox potential in MtrF”
    Journal Pubmed
  63. Keisuke Saito*Takumi Suzuki, and Hiroshi Ishikita
    J. Photochem. Photobiol. A 358 (2018) 422-431. doi: 10.1016/j.jphotochem.2017.10.003
    “Absorption-energy calculations of chlorophyll a and b with an explicit solvent model”
    Journal
  64. Keisuke Kawashima, Tomohiro Takaoka, Hiroki Kimura, Keisuke Saito, and Hiroshi Ishikita*
    Nat. Commun. 9:1247 (2018) doi: 10.1038/s41467-018-03545-w
    “O2 evolution and recovery of the water-oxidizing enzyme”
    Journal Pubmed
  65. Keisuke Kawashima and Hiroshi Ishikita*
    Chem. Sci. 9 (2018) 4083-4092. doi 10.1039/C8SC00424B
    “Energetic insights into two electron transfer pathways in light-driven energy-converting enzymes”
    Journal Pubmed
  66. Yoshitaka Saga*, Keiya Hirota, Sayaka Matsui, Hitoshi Asakawa, Hiroshi IshikitaKeisuke Saito*
    Biochemistry 57 (2018) 3075-3083. doi: 10.1021/acs.biochem.8b00259
    “Selective removal of B800 bacteriochlorophyll a from the light-harvesting complex 2 of the purple photosynthetic bacterium Phaeospirillum molischianum
    Journal Pubmed
  67. Keisuke KawashimaKeisuke Saito, and Hiroshi Ishikita*
    Biochemistry 57 (2018) 4997-5004. doi: 10.1021/acs.biochem.8b00574
    “Mechanism of radical formation in the H-bond network of D1-Asn298 in photosystem II”
    Journal Pubmed
  68. Keiichi Kojima, Hiroshi C. Watanabe, Satoko Doi, Natsuki Miyoshi, Misaki Kato, Hiroshi Ishikita, Yuki Sudo*
    Biophys. Physicobiol. 15 (2018) 179-188. doi: 10.2142/biophysico.15.0_179
    “Mutational analysis of the conserved carboxylates of anion channelrhodopsin-2 (ACR2) expressed in Escherichia coli and their roles in anion transport”
    Journal Pubmed
  69. Keisuke Saito and Hiroshi Ishikita*
    Biochim. Biophys. Acta  (Bioenergetics) 1860 (2019) 148059. doi: 10.1016/j.bbabio.2019.148059
    “Mechanism of protonation of the over-reduced Mn4CaO5 cluster in photosystem II”
    Journal Pubmed
  70. Hiroyuki Tamura*, Koki Azumaya, and Hiroshi Ishikita
    J. Phys. Chem. Lett. 10 (2019) 7623-7628. doi: 10.1021/acs.jpclett.9b03029
    “Long-range exciton diffusion via singlet revival mechanism”
    Journal Pubmed
  71. Keiichi Kojima, Tetsuya Ueta, Tomoyasu NojiKeisuke Saito, Kanae Kanehara, Susumu Yoshizawa, Hiroshi Ishikita, Yuki Sudo*
    Sci. Rep. 10 (2020) 282. doi: 10.1038/s41598-019-57122-2
    “Vectorial proton transport mechanism of RxR, a phylogenetically distinct and thermally stable microbial rhodopsin”
    Journal Pubmed
  72. Manoj Mandal, Keisuke Kawashima, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. 11 (2020) 249-255. doi: 10.1021/acs.jpclett.9b02831
    “Redox potential of the oxygen-evolving complex in the electron transfer cascade of photosystem II”
    Journal Pubmed
  73. Hiroyuki Tamura* and Hiroshi Ishikita
    J. Phys. Chem. A 124 (2020) 5081-5088. doi: 10.1021/acs.jpca.0c02228
    “Quenching of singlet oxygen by carotenoids via ultrafast super-exchange dynamics”
    Journal Pubmed
  74. Hiroyuki Tamura, Keisuke Saito, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 117 (2020) 6373-6382. doi: 10.1073/pnas.2000895117 [Direct Submission, Edited by P. Falkowski]
    “Acquirement of water-splitting ability and alteration of charge-separation mechanism in photosynthetic reaction centers”
    Journal Pubmed
  75. Naoki SakashitaHiroshi Ishikita, and Keisuke Saito*
    Phys. Chem. Chem. Phys. 22 (2020) 15831-15841. doi: 10.1039/d0cp00295j
    “Rigidly hydrogen-bonded water molecules facilitate proton transfer in photosystem II”
    Journal Pubmed
  76. Keisuke SaitoMinesato Nakagawa, and Hiroshi Ishikita*
    Commun. Chem. 3 (2020) 89. doi: 10.1038/s42004-020-00336-7
    “pKa of the ligand water molecules in the oxygen-evolving Mn4CaO5 cluster in photosystem II”
    Journal
  77. Keisuke SaitoManoj Mandal, and Hiroshi Ishikita*
    Biochemistry 59 (2020) 3216-3224. doi: 10.1021/acs.biochem.0c00177
    “Energetics of ionized water molecules in the H-bond network near the Ca2+ and Cl binding sites in photosystem II”
    Journal Pubmed
  78. Keiichi Kojima, Natsuki Miyoshi, Atsushi Shibukawa, Srikanta Chowdhury, Masaki TsujimuraTomoyasu NojiHiroshi Ishikita, Akihiro Yamanaka, and Yuki Sudo*
    J. Phys. Chem. Lett. 11 (2020) 6214-6218. doi: 10.1021/acs.jpclett.0c01406
    “Green-sensitive, long-lived, step-functional anion channelrhodopsin-2 variant as a high-potential neural silencing tool”
    Journal Pubmed
  79. Keisuke Saito*Koji Mitsuhashi, and Hiroshi Ishikita*
    J. Photochem. Photobiol. A 402 (2020) 112799. doi: 10.1016/j.jphotochem.2020.112799
    “Dependence of the chlorophyll wavelength on the orientation of a charged group: why does the accessory chlorophyll have a low site energy in photosystem II?”
    Journal
  80. Keisuke SaitoManoj Mandal, and Hiroshi Ishikita*
    Phys. Chem. Chem. Phys. 22 (2020) 25467-25473. doi: 10.1039/D0CP04265J
    “Redox potentials along the redox-active low-barrier H-bonds in electron transfer pathways”
    Journal Pubmed
  81. Manoj Mandal, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. 11 (2020) 10262-10268. doi: 10.1021/acs.jpclett.0c02868
    “The nature of the short oxygen-oxygen distance in the Mn4CaO6 complex of the photosystem II crystals”
    Journal Pubmed
  82. Masaki Tsujimura and Hiroshi Ishikita*
    J. Phys. Chem. B 124 (2020) 11819-11826. doi: 10.1021/acs.jpcb.0c08910
    “Insights into the protein functions and absorption wavelengths of microbial rhodopsins”
    Journal Pubmed
  83. Masaki TsujimuraTomoyasu NojiKeisuke Saito, Keiichi Kojima, Yuki Sudo, and Hiroshi Ishikita*
    Biochim. Biophys. Acta  (Bioenergetics) 1862 (2021) 148349. doi: 10.1016/j.bbabio.2020.148349
    “Mechanism of absorption wavelength shifts in anion channelrhodopsin-1 mutants”
    Journal Pubmed
  84. Hiroshi Kuroda1Keisuke Kawashima1, Kazuyo Ueda, Takuya IkedaKeisuke Saito, Ryo Ninomiya, Chisato Hida, Yuichiro Takahashi*, Hiroshi Ishikita*
    Biochim. Biophys. Acta (Bioenergetics) 1862 (2021) 148329. doi: 10.1016/j.bbabio.2020.148329
    “Proton transfer pathway from the oxygen-evolving complex in photosystem II substantiated by extensive mutagenesis”
    1These authors contributed equally to this work.
    Journal Pubmed
  85. Masaki Tsujimura* and Hiroshi Ishikita*
    J. Biol. Chem. 296 (2021) 100459. doi: 10.1016/j.jbc.2021.100459
    “Identification of intermediate conformations in the photocycle of the light-driven sodium-pumping rhodopsin KR2”
    Journal Pubmed
  86. Koji Mitsuhashi, Hiroyuki Tamura, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. B 125 (2021) 2879-2885. doi: 10.1021/acs.jpcb.0c10885
    “Nature of asymmetric electron transfer in the symmetric pathways of photosystem I”
    Journal Pubmed
  87. Manoj Mandal, Keisuke Saito, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. 12 (2021) 4032-4037. doi: 10.1021/acs.jpclett.1c00814
    “Two distinct oxygen-radical conformations in the X‑ray free electron laser structures of photosystem II”
    Journal Pubmed
  88. Hiroyuki Tamura*, Keisuke Saito, and Hiroshi Ishikita
    Chem. Sci. 12 (2021) 8131-8140. doi: 10.1039/D1SC01497H
    “Origin of unidirectional charge separation in photosynthetic reaction centers: nonadiabatic quantum dynamics of exciton and charge in the pigment-protein complexes”
    Journal Pubmed
  89. Keisuke Saito*, Minesato Nakagawa, Manoj Mandal, and Hiroshi Ishikita*
    Photosynth. Res. 148 (2021) 153-159. doi: 10.1007/s11120-021-00846-y
    “Role of redox-inactive metals in controlling the redox potential of heterometallic manganese-oxido clusters”
    Journal Pubmed
  90. Yu Sugo, Keisuke Saito, and Hiroshi Ishikita*
    Proc. Natl. Acad. Sci. U. S. A. 118 (2021) e2103203118. doi: 10.1073/pnas.2103203118
    “Mechanism of the formation of proton transfer pathways in photosynthetic reaction centers”
    Journal Pubmed
  91. Tomoki Kanda1, Keisuke Saito1, and Hiroshi Ishikita*
    J. Phys. Chem. Lett. 12 (2021) 7431-7438. doi: 10.1021/acs.jpclett.1c01896
    “Electron acceptor-donor Fe sites in the iron-sulfur cluster of photosynthetic electron-transfer pathways”
    1These authors contributed equally to this work.
    Journal Pubmed
  92. Katsumori Segawa1, Atsuo Kikuchi1, Tomoyasu Noji, Yuki Sugiura, Keita Hiraga, Chigure Suzuki, Kazuhiro Haginoya, Yasuko Kobayashi, Mitsuhiro Matsunaga, Yuki Ochiai, Kyoko Yamada, Takuo Nishimura, Shinya Iwasawa, Wataru Shoji, Fuminori Sugihara, Kohei Nishino, Hidetaka Kosako, Masahito Ikawa, Yasuo Uchiyama, Makoto Suematsu, Hiroshi Ishikita, Shigeo Kure, Shigekazu Nagata*
    J. Clin. Invest. 131 (2021) e148005. doi: 10.1172/JCI148005
    “A sublethal mutation in ATP11A that causes aberrant phosphatidylcholine flipping in plasma membranes”
    1These authors contributed equally to this work.
    Journal Pubmed
  93. Yasunori Saitoh1, Namiki Mitani-Ueno1, Keisuke Saito1, Kengo Matsuki, Sheng Huang, Lingli Yang, Naoki Yamaji, Hiroshi Ishikita, Jian-Ren Shen, Jian Feng Ma, and Michihiro Suga *
    Nat. Commun. 12 (2021) 6236. doi: 10.1038/s41467-021-26535-x
    “Structural basis for high selectivity of a rice silicon channel Lsi1”
    1These authors contributed equally to this work.
    Journal
  94. Taichi Tsuneishi1, Masataka Takahashi1, Masaki Tsujimura1, Keiichi Kojima, Hiroshi Ishikita, Yasuo Takeuchi, and Yuki Sudo*
    Front. Mol. Biosci. (2021) doi: 10.3389/fmolb.2021.794948
    “Exploring the retinal binding cavity of archaerhodopsin-3 by replacing the retinal chromophore with a dimethyl phenylated derivative”
    1These authors contributed equally to this work.
    Journal
  95. Masaki Tsujimura1, Keiichi Kojima1, Shiho Kawanishi, Yuki Sudo*, and Hiroshi Ishikita*
    eLife (2021) in press
    “Proton transfer pathway in anion channelrhodopsin-1”
    1These authors contributed equally to this work.
    preprint server
  96. Hiroyuki Tamura*, Keisuke Saito, and Hiroshi Ishikita
    J. Phys. Chem. B (2021) in press
    “Long-range electron tunneling from the primary to secondary quinones in photosystem II enhanced by hydrogen bonds with non-heme Fe complex”

OTHERS

  1. Irina Karyagina1, Yulia Pushkar, Dietmar Stehlik, Art van der Groot, Hiroshi Ishikita, Ernst-Walter Knapp, Bharat Jagannathan, Rufat Agalarov, and John H. Golbeck*
    Photosynthesis. Energy from the Sun (2008) pp. 101-104 (DOI: 10.1007/978-1-4020-6709-9_23)
    “The influence of aspartate 575PsaB on the midpoint potentials of phylloquinones A1A/A1B and the Fx iron-sulfur cluster in photosystem I”
  2. Keisuke Saito and Hiroshi Ishikita*
    Nature Precedings(2011) doi:10.1038/npre.2011.6486.1
    “Cationic state distributions over chlorophyll pairs in photosystem I and II”
  3. Hiroshi Ishikita*
    Handbook of Flavoproteins Vol.2. (Verlag Walter de Gruyter GmbH & Co. KG, Berlin) pp321-333
    “Contributions of protein environment to the reduction potentials of flavin-containing proteins”
  4. Hiroshi Ishikita*
    Kyoto University Research Activities (2013) Vol2, No.3, pp23
    “Research Frontiers: How Do Green Plants Produce O2 from Water?”
  5. Hiroshi Ishikita*
    Oxygen Production and Reduction in Artificial and Natural Systems (James Barber, Alexander V Ruban, and Peter J Nixon, Eds.) (2019) pp 191-208, World Scientific, doi: 10.1142/9789813276925_0010, ISBN: 978-981-3276-93-2
    “Protein Environment that Facilitates Proton Transfer and Electron Transfer in Photosystem II”
  6. Hiroshi Ishikita* and Keisuke Saito
    Microbial Photosynthesis (Wang, Qiang, Ed.) (2020) pp 115-120, Springer Nature, doi: 10.1007/978-981-15-3110-1_5, Online ISBN 978-981-15-3110-1, Print ISBN 978-981-15-3109-5
    “Redox potentials of quinones in aqueous solution: Relevance to redox potentials in protein environments”